RT Journal Article
SR Electronic
T1 Significance of protein S in patients with interstitial lung disease
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P714
VO 40
IS Suppl 56
A1 Masahiro Naito
A1 Osamu Taguchi
A1 Kentaro Fujiwara
A1 Masahiro Onishi
A1 Takehiro Takagi
A1 Tetsu Kobayashi
A1 Hiroyasu Kobayashi
A1 Corina D'Alessandro-Gabazza
A1 Esteban Gabazza
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P714.abstract
AB Background: Protein S exerts anticoagulant activity by acting as a cofactor of activated protein C for the inactivation of coagulation factors Va and VIIIa. We have previously reported that protein S protects against lipopolysaccharide-induced acute lung injury by directly inhibiting the local expression of inflammatory cytokines without affecting coagulation (Takagi T, et al. 2009). However, the role of protein S in interstitial lung disease remains unclear. Objective: The aim of this study is to evaluate the clinical significance of protein S in patients with interstitial lung disease. Methods: This study comprised 106 patients with interstitial lung disease admitted in our institution between August 2008 and December 2011. There were 39 patients with interstitial pneumonia, 25 with sarcoidosis, 9 with collagen vascular disease-associated interstitial lung disease, 8 with organizing pneumonia, 7 with eosinophilic pneumonia, 5 with tumor-associated lung disease, 5 with inflammatory disease, 4 with hypersensitivity pneumonitis, 2 with IgG4 related multi-organ lymphoproliferative syndrome, 1 with alveolar proteinosis, and 1 patient with alveolar hemorrhage. Levels of protein S in BALF were measured using an enzyme-linked immunosorbent assay. Results: Significant changes in the BALF levels of protein S were observed among the different types of interstitial lung diseases. The BALF level of protein S was significantly correlated with the number of macrophages, lymphocytes and with the BALF concentration of total protein and albumin. Conclusion: These results suggest that protein S plays role in the pathogenesis of interstitial lung disease.