RT Journal Article
SR Electronic
T1 Serum aminotransferase levels in patients with severe obstructive sleep apnea
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P3814
VO 40
IS Suppl 56
A1 Parisa Adimi
A1 Froogh Soltani
A1 Nazanin Kiapour
A1 Zohreh Mohammad Taheri
A1 Nader Fayazi
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P3814.abstract
AB BackgroundObstructive sleep apnea (OSA) is one of the most common sleep disorders with a plethora of consequences. Currently the impact of hypoxia due to OSA on liver function is targeted growing attention. This study evaluated the association between serum aminotransferase levels as accepted predictive factor for liver injury and factors connected with OSA severity (apnea hypopnea index (AHI), lowest oxygen saturation level, oxygen desaturation index (DI), percent of time below 90% saturation [T<90%]).Materials and Methods66 patients with BMI≥30, who their OSA was confirmed by PSG, were divided equally into two groups based on AHI. 33 patients in control group with 5<AHI<15, and 33 patients in case group with AHI≥30 events/hours were enrolled. We compared serum level of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) with OSA severity factors in each group.ResultMean DI was (56.33 ± 26.97) (14.00 ± 10.46) in case and control group respectively (P-value <0.001). T<90% was (33)100%and (14)42.4% in case and control group respectively (P-value <0.001). A significant different in mean DI level and T<90% were observed.In case and control group,respectively,mean levels of AST (21.33 ± 8.62), (21.15±9.39) and ALT (24.24 ± 14.07), (19.82 ±9.74) were not significantly different{(P-value=0.935) (P-value = 0.142)}. Pearson correlation test showed there is a weak relation between mean DI,T<90%,AST (0.969) and ALT (P=0.837).ConclusionsThis study showed there is no significant correlation between serum aminotransferase levels and OSA severity.