RT Journal Article SR Electronic T1 Combined pulmonary fibrosis and emphysema syndrome (CFPE) JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P715 VO 40 IS Suppl 56 A1 Francisco Muñiz A1 Inmaculada Herráez A1 Elena Bollo A1 Silvia Fernández A1 Beatriz Cartón A1 Emilio Santalla A1 Florentino Diez YR 2012 UL http://erj.ersjournals.com/content/40/Suppl_56/P715.abstract AB Introduction: CPFE is a clinic entity which consists in the coexistence of emphysema of the upper lobes and pulmonary fibrosis of the lower lobes. Method: Retrospective descriptive study of cases diagnosed of CPFE between 2007 and 2012. Results: 44 patients, all of them men, with an average age of 69 years. All were current or ex smokers. 50% had a UIP (usual interstitial pneumonia) pattern at the HRTC, 11.4% possible UIP pattern, and 38.6 % inconsistent UIP pattern. All the patients had emphysema, above all paraseptal and centrilobular. PAH was present in 10 patients. The final diagnosis was: 18 IPF, 1 possible IPF,1 NSIP, 3 possible NSIP, 6 fibrosis associated connective tissue diseases, 1 asbestosis, 1 hypersensitivity pneumonitis, 1 drug associated fibrosis, and 12 non classificable interstitial pneumonias. During follow-up 8 patients died, 6 were diagnosed of lung cancerView this table:ResultsConclusions: All of the patients from this study are men with smoking history. These patients have, lung volumes preserved with a severe impairment of gas exchange. The high prevalence of PAH and its important role in the prognosis justify echocardiography. As these patients might have a high prevalence of lung cancer, a close follow-up would be advisable.