RT Journal Article
SR Electronic
T1 The use of respiratory functional imaging to get better understanding of lung resection surgery
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 3301
VO 40
IS Suppl 56
A1 Wim Vos
A1 Cedric Van Holsbeke
A1 Annelies Janssens
A1 Samir Vinchurkar
A1 Jan De Backer
A1 Wim D'hondt
A1 Wilfried De Backer
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/3301.abstract
AB AimThe aim of the present study was to get a better understanding of the impact of lung resection surgery (LRS) on the respiratory function using respiratory functional imaging (RFI).Method7 patients underwent either a single (5/7) or double lobectomy (1/7), or a full pneumectomy (1/7). All patients underwent lung function tests and CT based RFI providing imaged Raw (iRaw), airway volume (iVaw) and internal flow distribution before and after surgery.ResultLRS causes deformation of the airways (see figure), a significant drop in FEV1 (p=0.02), TCO (p=0.02) and VA (p=0.02) and an increase in Raw (p=0.03). RFI shows decreased airway volume (iVaw,p=0.02) and increased resistance (iRaw,p=0.02). Changes in both iVaw and iRaw did correlate with changes in FEV1 (p=0.007 and p=0.02). If iVaw, iRaw and lobar flow were recalculated after virtual resection, these data did correlate well with the observed postoperative data (R²=0.8,p<0.01; R²=0.55,p<0.01; R²=0.45,p<0.01).ConclusionRFI does provide insights in the influence of LRS on the postoperative airway volumes, resistances and internal flow redistribution and can be used to predict post-operative lung mechanics.