PT  - JOURNAL ARTICLE
AU  - Wim Vos
AU  - Cedric Van Holsbeke
AU  - Annelies Janssens
AU  - Samir Vinchurkar
AU  - Jan De Backer
AU  - Wim D'hondt
AU  - Wilfried De Backer
TI  - The use of respiratory functional imaging to get better understanding of lung resection surgery
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - 3301
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/3301.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/3301.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - AimThe aim of the present study was to get a better understanding of the impact of lung resection surgery (LRS) on the respiratory function using respiratory functional imaging (RFI).Method7 patients underwent either a single (5/7) or double lobectomy (1/7), or a full pneumectomy (1/7). All patients underwent lung function tests and CT based RFI providing imaged Raw (iRaw), airway volume (iVaw) and internal flow distribution before and after surgery.ResultLRS causes deformation of the airways (see figure), a significant drop in FEV1 (p=0.02), TCO (p=0.02) and VA (p=0.02) and an increase in Raw (p=0.03). RFI shows decreased airway volume (iVaw,p=0.02) and increased resistance (iRaw,p=0.02). Changes in both iVaw and iRaw did correlate with changes in FEV1 (p=0.007 and p=0.02). If iVaw, iRaw and lobar flow were recalculated after virtual resection, these data did correlate well with the observed postoperative data (R²=0.8,p<0.01; R²=0.55,p<0.01; R²=0.45,p<0.01).ConclusionRFI does provide insights in the influence of LRS on the postoperative airway volumes, resistances and internal flow redistribution and can be used to predict post-operative lung mechanics.