TY - JOUR T1 - Obstructive sleep apnea syndrome and cardiovascular diseases risk in patients with COPD JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P885 AU - O.S. Khmel' AU - L.A. Glinyana AU - A.A. Molchanov AU - V.V. Rodionova Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P885.abstract N2 - Purpose: to define the correlation between obstructive sleep apnea syndrome (OSAS) and increasing of cardiovascular risk in patients with chronic obstructive pulmonary diseases (COPD).Design:There were examined 33 patients in the age of 63,93±1,59 years with COPD stage 2 (85%) and stage 3 (15%). Duration of disease was: 10-14 years – 22 patients (67%) and 15-24 years–11 patients (33%). 60% of patients were smoking, index of smoking - 14,7±0,48 pack-years. Control group included 10 practically healthy persons. Methods: Holter monitor test with rheopneumography, spirometry, X-ray examination, six-minute walk test, calculation of cardiovascular risk according to the scale SCORE (Systematic Coronary Risk Evaluation). Patients received basic therapy according to the recommendations of GOLD, 2009. Results: 62% of patients had OSAS of mild stage and 38% - had OSAS of moderate stage (p<0,05). Duration of apnea cases varied from 259,0-1240,0 sec. 82% of patients had from 90 to 13990 cases of cardiac rhythm disturbances within 24 hours. Extremity index of heart rate (EIHR) varied during sleep - 2,1456±0,19. There were revealed correlations between duration of apnea cases and cardiovascular diseases risk (r=0,7136; p<0,05), number of heart rhythm disorders (r=0,7373; p<0,05), general cholesterol (r=0,7269; p<0,05). There was correlation between EIHR during sleep and OSAS (r=0,77; p<0,05). Patients had evidently increased risk for fatal complications according to the scale SCORE (r=0,8139; p<0,05): high risk level in 12,5% and very high - in 75% of cases. Conclusions: Patients with both COPD and OSAS have evidently increased risk for fatal complications. ER -