TY - JOUR T1 - Ventilatory responses during 6-min walk test in stable COPD patients JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P637 AU - Masahiro Satake AU - Takanobu Shioya AU - Hitomi Takahashi AU - Keiyu Sugawara AU - Chikage Kasai AU - Noritaka Kiyokawa AU - Toru Watanabe AU - Sayaka Sato AU - Atsuyoshi Kawagoshi AU - Mitsunobu Homma Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P637.abstract N2 - Aim: The purpose of this study was to evaluate the ventilatory responses during the 6-minute walking test (6MWT) in stable COPD patients.Subjects and Methods: 23 patients with stable COPD (23 male, age; 75.5 ± 6.4 years (mean±SD), BMI; 22.5 ± 3.8, FEV1: 56.1 ± 21.2 %pred) took part in this study. Throughout the 6MWT, oxygen uptake (V'O2), carbon dioxide production (V'CO2), minute ventilation (V'E), and heart rate (HR) were measured using a portable cardiopulmonary exercise system (MetaMax 3B, Cortex, Germany). Dyspnea and oxygen saturation were recorded at the end of each minute during the 6MWT. Dyspnea was measured using the Borg 0-10 dyspnea scale. The IC was measured at every two minute during the 6MWT. These data were compared with those of incremental cycle ergometer test (ICET)Results: This study showed that the distance walked in the 6MWT was 505.7 ± 100.4 m, the peak V'O2 was 12.9 ± 2.5 ml/min/kg, the peak V'CO2 was 12.5 ± 3.2 ml/min/kg, the peak V'E was 28.2 ± 9.2 L/min, the Borg dyspnea scale at the end of the 6MWT was 4.6 ± 2.2, and the oxygen saturation showed 89.3 ± 2.9 %. During the 6MWT, V'E/V'O2 and V'E/V'CO2 curve decreased for 2 minutes, and then showed a leveling off, while these curve inflected upward during the ICET.Conclusions: These data suggested that the ventilation equivalent at two minutes was most efficient and that respiratory metabolism was below anaerobic threshold during the 6MWT in stable COPD patients. ER -