RT Journal Article
SR Electronic
T1 Evaluation of cut-off values of QuantiFERON-TB Gold, interferon gamma inducible protein-10 and tuberculin skin test in active tuberculosis diagnosis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P425
VO 40
IS Suppl 56
A1 Seyhan, Ekrem
A1 Köksalan, Kaya
A1 Günlüoglu, Gülsah
A1 Sökücü, Sinem
A1 Veske, Nurdan
A1 Akbas, Aysegül
A1 Altin, Sedat
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P425.abstract
AB Aim: The diagnostic accuracy of interferongamma- based assays for Mycobacterium tuberculosis infection may be improved by using lower cut-off values for the tuberculin skin testing (TST), QuantiFERON-TB Gold (QFT) and Interferon gamma inducible protein (IP)-10.Methods: A total of 70 adult TB patients and 81 healthy controls were included for this study.Three assays, TST, QFT and (IP)-10, were evaluated for their diagnostic performance with respect to different cut-off values. Test cut-offs were established based on receiver operating characteristic curve analysis.Results: The sensitivities of the assays were: TST 40 %, QFT 87 % and IP-10 85 %, while their specificities were TST 58 %, QFT 71 % and IP-10 74 %. Both QFT and IP-10 were significantly more specific than TST (both P< 0.001), but were similiar to each other (P > 0.5). Receiver operating characteristic analysis revealed that a cut-off value of 0.29 IU/ml for QFT and 1857 IU/ml for IP-10 maximises specificity without significant loss of test sensitivity. Using lower cut-off values for TST, however, also increased the sensitivity of the assay but resulted in a significant decrease in specificity.Conclusions: Lower cut-off values for TST, QFT and (IP)-10 increased the sensitivity of each assay, but a lower cut-off value for QFT and (IP)-10 could specificity be maintained.