RT Journal Article SR Electronic T1 CURB-65 scoring utilization in predicting mortality of hospitalized patients with AE-COPD JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P738 VO 40 IS Suppl 56 A1 Ghazal Shaista A1 Nusrat Idrees A1 Kumar Panjwani A1 Hayat Muhammad A1 Rizvi Nadeem YR 2012 UL http://erj.ersjournals.com/content/40/Suppl_56/P738.abstract AB AE-COPD is a commonly encountered problem in COPD patients leading to expensive in patient treatment and ICU admissions. It is associated with significant mortality.Historically CURB-65 score is used to predict mortality in CAP and there is no scoring system to predict the mortality in hospitalized AE-COPD patients. This study is designed to evaluate the validation of CURB-65 score in predicting mortality in AE-COPD hospitalized patients.This is a retrospective study conducted at JPMC, Karachi, Pakistan. Charts reviewed from July 2010 to June 2011 of hospitalized patients; only AE-COPD included in the study. Patients with other respiratory diseases (asthma, bronchiectesis, ILD and consolidation on chest x-ray or incomplete charts were excluded). CURB-65 was defined as C=Altered level of consciousness (GCS <13), U = urea >7mmol/l, R = Respiratory rate >35breaths/min, B= Blood pressure (SBP <90mmHg or DBP <60mmHg) and age is >65 years, one point awarded for each. Chi- square test was used to see statistical significance of mortality difference in CURB-65 groups.200 charts reviewed; 97 incomplete charts; 38 patients with ILD, brochictesis, asthma PNA. 65 patients met the inclusion criteria. A direct correlation was observed between mortality and CURB-65; highest mortality noted with CURB-65 3-5. In hospital mortality in different CURB-65 groups were, low risk (score 0-1)10.0% (2/32), moderate risk score (2) 10.0% (2/12) and high risk (score 3-5) 80.0% (16/21).The CURB-65 scoring system is effective in predicting mortality in AE-COPD; can be used in AE COPD to stratify patients into different management groups as our conclusion indicates CURB 65 is helpful in assessing severity in AE COPD.