RT Journal Article
SR Electronic
T1 Effectiveness of the use of heliox on nebulizer associated with noninvasive ventilation in chronic obstructive pulmonary disease patients: A randomized controlled trial
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 2856
VO 40
IS Suppl 56
A1 Vitória Lima
A1 Cyda Reinaux
A1 Luciana Alcoforado
A1 Shirley Campos
A1 Catarina Rattes
A1 Simone Brandão
A1 Valdecir Galindo Filho
A1 Armèle Dornelas de Andrade
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/2856.abstract
AB Objective: To evaluate the efficacy of nebulized bronchodilators carried by heliox associated with NIV in the pulmonary deposition of radioaerosol in patients with stable COPD. Methods: A randomized controlled trial involving 37 patients divided into four groups: heliox NIV, oxygen NIV, heliox and oxygen. For scintigraphy pulmonary inhalation dose was administered a dose of dietilnotriaminopentaacético acid labeled with technetium(99mTc-DTPA- 25 mCi) combined with fenoterol bromide(0.12 mg) and ipatropium bromide(0.25 mg) delivered through a bi-level noninvasive ventilation system using a face mask with two unidirectional valves and connected to the nebulizer for radioisotopes(IPAP = 10 cm H2O and EPAP=8 cm H2O). Images were acquired immediately after the intervention using a Gama camera and Regions of interest was determined. Results: There was a higher radioaerosol pulmonary deposition in the lower third in the heliox NIV and oxygen NIV groups compared to oxygen group(p=0.03 and p=0.02, respectively). We observed a higher deposition in the middle third(p=0.008) in heliox NIV group when compared to O2. Thus, there was a positive correlation gain in inspiratory capacity(IC) and the total area of the right lung(p=0.04, r=0.71) in the heliox NIV group. Conclusion: Our results suggest that coupling heliox or oxygen with bi-level NIV reached a higher lung radioaerosol deposition in the lower third for both lungs. The association between heliox and NIV seem to be more effective to promote a higher radioaerosol peripheral deposition considering the gain of the IC.Supported by: CAPES NF, CNPq, FACEPE.