PT - JOURNAL ARTICLE AU - Faheem Khan AU - Orla Cotter AU - Jim Clair AU - David Curran AU - T. O'Connor TI - Impact of Quantiferon TB Gold intensity response in active over latent tuberculosis DP - 2012 Sep 01 TA - European Respiratory Journal PG - P419 VI - 40 IP - Suppl 56 4099 - http://erj.ersjournals.com/content/40/Suppl_56/P419.short 4100 - http://erj.ersjournals.com/content/40/Suppl_56/P419.full SO - Eur Respir J2012 Sep 01; 40 AB - We sought to determine whether the intensity of response in patients with a positive Quantiferon-TB Gold assay (QTF) was predictive of active over latent tuberculosis, and whether other factors determined the intensity of response.We analyzed positive Quantiferon assays (Cellestis, Carnegie, Australia) performed between July 2009 and April 2011 in the Mercy University Hospital, Cork. The group consisted of 94 patients with latent tuberculosis and 35 patients with active tuberculosis.There was no difference in the intensity of response between patients with latent and active tuberculosis (p=0.1589). In patients with latent tuberculosis, there were no correlations between age (p=0.353), sex (p=0.476), smoking status (p=0.323), contact history (p=0.612), Mantoux response (p=0.055), Irish nationality (p=0.768), previous BCG vaccination (p=0.504), WCC (p=0.187), peripheral lymphocyte count (p=0.786), neutrophil count (p=0.157) and the intensity of QTF response. Similarly in active TB group there is no correlation found between mentioned variables and QTF response.The intensity of QTF response does not help to differentiate active from latent tuberculosis. In adults with tuberculosis, the intensity of QTF response is not influenced by age, sex, smoking, remoteness of contact history, Mantoux response, nationality, CXR abnormalities, BCG vaccination and peripheral lymphocyte count.