TY - JOUR T1 - Scintigraphic parameters in bronchial asthma patients JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P1707 AU - Tatyana Ageeva AU - Nikolay Krivonogov AU - Anna Dubodelova Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P1707.abstract N2 - Aim: to study the ventilation-perfusion ratio (V/Q), apex-base gradient of ventilation (U/L-V) and perfusion (U/LQ) and alveolar-capillary permeability (ACP) in bronchial asthma (BA) patients on the basis of scintigraphy data.Materials and methods: 30 people aged 18-60 took part in the study: patients diagnosed with BA (20) and healthy non-smoking volunteers (20). The scintigraphic studies were performed by means of Omega 500 gamma camera (Technicare, USA-Germany). The subject of the research was an examination of ACP in the right (RL) and left (LL) lungs in the process of radiopharmaceutical derivation, static conditions, during the 1st, 10th and 30th min after 99mTc DTPA inhalation.Results: BA patients: V/Q in both RL and LL was not higher than 1.0 and amounted to 0.98 (0.92-1.04) in the RL and 0.98 (0.95-1.01) in the LL. These parameters did not differ from those of healthy volunteers (p=0.72 and p=0.65). U/L-V amounted to 0.55 (0.33-0.77) in the RL and 0.57 (0.45-0.69) in the LL. It was lower than that of healthy people (p=0.03 and 0.04). U/LQ amounted to 0.82 (0.66-0.98) in the RL and 1.1 (0.84-1.36) in the LL. This parameter was higher than that of healthy people (p=0.004, p=0.02). ACP in the RL amounted to 10.19% (6.49-14.19%) and 27.21% (22.99-31.41%) during the 10th and 30th minutes of the study, respectively; it was increased during the 30th minute (p=0.001). ACP in the LL amounted to 9.68% (8.49-10.87%) and 27.87 (24.26-31.48%) during the 10th and 30th minutes of the study, respectively; it was increased during the 30th minute of the study (p=0.002).Conclusions: The study findings may serve as additional scintigraphic criteria for bronchial asthma diagnostics. ER -