RT Journal Article SR Electronic T1 A retrospective clinical and radiological review of 20 Castleman's disease cases JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P1777 VO 40 IS Suppl 56 A1 Yasunori Ichimura A1 Jiro Terada A1 Yusuke Naito A1 Tetsuo Fujita A1 Takashi Urushibara A1 Ayako Shigeta A1 Takayuki Sakurai A1 Ken Iesato A1 Fuminobu Kuroda A1 Yuji Tada A1 Seiichiro Sakao A1 Katsushi Kurosu A1 Yasunori Kasahara A1 Nobuhiro Tanabe A1 Yuichi Takiguchi A1 Koichiro Terada YR 2012 UL http://erj.ersjournals.com/content/40/Suppl_56/P1777.abstract AB [RATIONALE] Castleman's disease is one of the rare lymph proliferative diseases, which usually involves lung. There is still no established standard therapy at the moment. We have examined the clinical findings including therapies and prognoses. [METHODS] On the cases of Castleman's disease consulted in our hospital in the past 10 years until 2011, we retrospectively examined based on the medical records. [RESULTS] The study comprised 20 patients (70% male) with a mean age of 55 (25-70) years old. As complications, 6 cases had POEMS syndrome (2 with PH), 3 had hematologic diseases (DLBCL, ITP, MDS). By chest CT, mediastinal adenopathy was confirmed in all cases, 10 were confirmed with lung involvement (5: nodular shadow; 2: reticulonodular shadow; 4: GGO; 5: interlobular septal thickening), 6 with pleural effusion, and 3 with cardiac effusion. The diagnostic methods were 13 cases of surgical lymph node biopsy, 6 cases of lung biopsy (2: TBLB; 2: VATS lung biopsy; 1: open lung biopsy; 1: CT-guided lung biopsy), 1 case of lachrymal gland biopsy. Histopathologically, there were 4 cases of hyaline vascular type and 16 cases of plasma cell type. 4 cases were prioritized on the treatment for complications (3: POEMS syndrome; 1: ITP), and 2 were left untreated for a follow-up. Treatment was started for 14 cases using PSL at the time of diagnosis or exacerbation of symptom. [CONCLUSIONS] In this study, lung biopsies are useful as diagnostic method in the cases with pulmonary involvement. Few cases were confirmed with reduction of lymph node and improvement of lung involvement by treatment. But in many cases symptomatic improvement or suppression of the progress of the disease by the treatment were observed.