PT - JOURNAL ARTICLE AU - Christopher Jeanes AU - Claire Brockwell AU - Allan Clark AU - Andrew Wilson TI - Relationship between patient pulmonary function, exercise capacity and quality of life in chronic obstructive pulmonary disease (COPD) DP - 2012 Sep 01 TA - European Respiratory Journal PG - P863 VI - 40 IP - Suppl 56 4099 - http://erj.ersjournals.com/content/40/Suppl_56/P863.short 4100 - http://erj.ersjournals.com/content/40/Suppl_56/P863.full SO - Eur Respir J2012 Sep 01; 40 AB - Background: Six minute walk testing (6MWT) and spirometry predict survival & morbidity in COPD. Impulse oscillometry (IOS) is superior to spirometry in predicting patient reported outcomes in COPD. The aim of this cross sectional study was to explore the relationship between spirometry, IOS and airways resistance using the interrupter technique (RINT) versus 6MWT and health related quality of life (HQOL).Methods: Thirty-two (20 male) patients mean age 66yrs with COPD completed forced expiratory volume in 1 second (FEV1), IOS, RINT, 6MWT (with measurement of walking distance and desaturation) and St George's respiratory questionnaire (SGRQ). Spearman's rank correlation was used to examine the relationship between the measurements.Results: Peripheral and small airways resistance and RINT were associated with 6MWD and desaturation.View this table:Correlation Co-efficients for pulmonary function vs disease activityIOS outcomes were more strongly associated with St George's activity score than FEV1 or RINT. Other components of SGRQ were not correlated with any physiological measures evaluated.Conclusion: Although IOS was better than spirometry at predicting HRQOL; IOS and RINT were no better at predicting 6 minute walk distance than FEV1 and were inferior to FEV1% predicted at predicting 6 minute walk desaturation.