PT  - JOURNAL ARTICLE
AU  - Emelie Ekkernkamp
AU  - David Walker
AU  - Jan Hendrik Storre
AU  - Wolfram Windisch
AU  - Michael Dreher
TI  - Impact of intelligent volume assured pressure support on sleep quality, compliance and gas exchange in patients with stable hypercapnic COPD
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - P2064
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/P2064.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/P2064.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - Introduction: Noninvasive positive pressure ventilation (NPPV) using the technique of high-intensity-NPPV (HI-NPPV) has been shown to treat hypoventilation in stable hypercapnic COPD patients with an overall good sleep quality (SQ). iVAPS (intelligent volume assured pressure support) using target alveolar ventilation is a hybrid mode of NPPV. Its impact on SQ still needs to be addressed. The aim of the study was to compare SQ and gas exchange using iVAPS and HI-NPPV in hospital and at home.Methods: In a randomized crossover design patients used iVAPS and HI-NPPV. Objective and subjective SQ as well as comfort with NPPV were assessed by polysomnography and questionnaires. Blood gas measurements were performed in hospital and at home. (Figure 1)Results: 14 patients were included. Beside applied pressure being rated more disturbing with iVAPS, there was no further difference with regard to SQ in hospital. At home, patients reported more restful sleep using iVAPS. There was no difference in daily usage (6.2±1.6 vs. 6.5±1.3h, p=0.27). PaCO2 in hospital was lower during iVAPS (41±8mmHg vs. 44±7 mmHg; p=0.04), whereas no difference was found at home (43±7 vs. 44±10mmHg; p=0.37).Conclusion: NPPV using iVAPS and HI-NPPV revealed no differences in SQ in hospital. At home, patients reported more restful sleep during iVAPS without differences in comfort with NPPV and daily usage.