PT  - JOURNAL ARTICLE
AU  - B. Salhi
AU  - C. Haenebalcke
AU  - S. Bogerd-Perez
AU  - M. Nguyen
AU  - K. Vermaelen
AU  - V.F. Surmont
AU  - G. Van Maele
AU  - J.P van Meerbeeck
AU  - E. Derom
TI  - Effects of radical treatment in patients with intrathoracic cancer
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - P4161
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/P4161.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/P4161.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - Introduction: In patients (pts) with intrathoracic cancer radical treatment aims to prolong life and restore quality of life. Data on its effect on exercise capacity and muscle force are limited.Aim: To investigate the effect of radical treatment on exercise capacity, muscle force and quality of life in pts with newly diagnosed intrathoracic cancer. Methods: Exercise capacity, peripheral muscle force and quality of life were assessed before and after radical therapy. Data are presented as median with 95% CI. Results (table): 117 pts (86 male, age: 64 y (47 - 77), BMI: 25 kg/m2 (18 - 34), 40% COPD; 35 PY (0 - 70)) 105 NSCLC, 6 SCLC and 6 mesothelioma were enrolled: 50% underwent surgery as sole therapy, 12% surgery + chemotherapy, 24% chemotherapy + radiotherapy, 10% surgery + chemotherapy + radiotherapy and 4% radiotherapy only. 24 pts dropped out and 18 are still under treatment. The maximal exercise capacity and 6MWD decreased significantly after treatment (from 100 Watt (48 - 184) to 82 Watt (38 – 147) and from 515 m (388 - 632) to 482 m (328 – 617)), respectively. Fatigue and pain increased significantly after treatment: FACT-F from 9 pnts (3 - 30) to 13 pnts (3 - 33) and VAS pain from 1 pnts (0 - 9) to 2 pnts (0- 8)). Conclusion: Radical therapy for intrathoracic cancer significantly decreases exercise capacity, muscle force, and increases pain and fatigue. Mature data on all pts will be available at the meeting.*: P<0.05.