TY - JOUR T1 - Lung cancer metabolomics in plasma, urine and broncheoalveolar lavage. A pilot study JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P4217 AU - Ricardo Aguilar AU - Eva Vázquez AU - Antonio Ruiz AU - Rocío Castilla AU - Raúl González AU - Jesús Grávalos AU - Tamara García AU - Jose Luis Gómez-Ariza AU - Jose Antonio Maldonado AU - Antonio Pereira-Vega Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P4217.abstract N2 - Lung cancer (LC) has high morbimortality rates. Today, research in biomarkers is a hot topic, and among these, the least frequently studied, are those of the metabolomics field.Our aims are to present preliminary data using metabolomics technics for detection of differentiated patterns between patients with LC and non-lung cancer (NLC) patients, to obtain an effective screening method.We obtained blood, urine, and broncheoalveolar lavage (BLA) samples from a group of patients who underwent bronchoscopy, for further analysis through mass spectrometry methods. These techniques provide us with metabolic fingerprinting, allowing the study of the metabolites involved in the process.Identification of the resultant metabolites was performed trough mass-mass fragmentation procedures. Guided by mass spectrum, the results where processed by Partial Least Squares Discriminant Analysis. We compared the results from both groups.Initially, 7 LC patients and 7 NLC subjects' samples were included. We found differences in metabolite profiles among these groups, allowing us to differentiate between LC and NLC cases. Including the blood and urine samples, we where able to identify potentially overexpressed markers, such as choline, phosphocholine and propionylcarnitine, leaving analysis of BLA samples results pending.In conclusion, both groups shown different metabolomics profiles in the analyzed samples, this allows for its statistic discrimination.Metabolites that are responsible for this discrimination have been identified and correlated with previously described neoplastic processes.The preliminary data raises the possibility of further studies that will allow the development of early screening technics. ER -