PT  - JOURNAL ARTICLE
AU  - Eleni Armeniakou
AU  - Georgia Perpati
AU  - Nikolaos Barouchos
AU  - Frixos Kopsahilis
AU  - Michalis Vaias
AU  - Aristea Christou
AU  - Eleni Pouliou
AU  - Serafim Nanas
TI  - Prolonged oxygen kinetics during submaximal cardiopulmonary exercise testing (CPET) in adult patients with cystic fibrosis (CF) and their relationship with indices of oxidative capacity
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - P1454
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/P1454.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/P1454.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - Background: Patients with cystic fibrosis demonstrate reduced exercise capacity. As the submaximal exercise testing overcomes many of the limitations of maximal exercise testing, indices of submaximal exercise capacity like time constant (τon) are of increased investigational interest. Aim: To compare oxygen kinetics of submaximal exercise testing between patients with cystic fibrosis and healthy controls and explore their relationship with indices of oxidative capacity. Patients-Methods: 14 adult patients with CF (8 males/6 females, mean age 22) and 10 healthy controls (5 males/5 females, mean age 29) submitted to maximal and submaximal CPET. We have calculated: τon during submaximal CPET, peak oxygen consumption (VO2peak) during maximal CPET, anaerobic threshold (AT) as a percentage of VO2peak and the slope of recovery after maximal CPET as it is expressed by the ratio of oxygen consumption to time (VO2/t slope). Results: The main finding is that τon in control group is significantly lower (29.35 s ± 6.38s) than τon in CF group (42.35 s ± 21.55 s, p<0.05). Moreover, a statistically significant negative correlation is found between τon and indices of oxidative capacity of maximal CPET such as:VO2peak (r = -0.533, p = 0.049), AT % (r= -0.645, p =0.013) and VO2/t slope (r = -0.576, p=0.031). Conclusion: Oxygen kinetics of submaximal CPET in adult patients with cystic fibrosis are prolonged and they are correlated with indices of oxidative capacity during maximal CPET.