PT  - JOURNAL ARTICLE
AU  - Yuichiro Machida
AU  - Yoshimichi Ueda
AU  - Miyako Shimazaki
AU  - Motoyasu Sagawa
AU  - Tsutomu Sakuma
TI  - Global histone H3 lysine 4 (H3K4) dimethylation is an important prognostic factor in lung cancer
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - P1216
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/P1216.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/P1216.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - [Introduction]Epigenetic modifications may contribute to the development and progression of cancer. This study seeks to elucidate the role of global histone modifications as a clinicopathological factor in lung cancer.[Methods]A series of 92 surgical specimens from patients with lung cancer were utilized from the surgical files of Kanazawa Medical University Hospital between 2001 and 2008. The 92 tumor specimens were examined by immunohistochemistry. Dimethylated histone 3 lysine 4 (H3K4diMe), Acetylated histone 3 lysine 9 (H3K9Ac), acetylated histone 3 lysine 18 (H3K18Ac), trimethylated histone 3 lysine 27 (H3K27trime), himethylated histone 4 arginine 3 (H4R3diMe) was assessed in paraffin-embedded tumor samples. They were dichotomized into two categories as low expression and high expression. The association between staining intensity and clinicopathological factor was analyzed.[Results]Lung cancers of various histologic subtypes showed that dimethylated histone 3 lysine 4 (H3K4diMe), acetylated histone 3 lysine 9 (H3K9Ac), acetylated histone 3 lysine 18 (H3K18Ac), trimethylated histone 3 lysine 27 (H3K27trime), dimethylated histone 4 arginine 3 (H4R3diMe) were high expressed in tumor cells of 40, 10, 9, 9, 10%. Expression of dimethylated histone 3 lysine 4 (H3K4diMe) correlated positively with recouurence (p=0.039) and stage (p=0.005) and cell differentiation (p=0.002). Univariate analysis showed that high expression of dimethylated histone 3 lysine 4 (H3K4diMe) correlated with recouurenc[Conclusion]We hypothesize that expression of H3K4diMe may be considered as a significatnt factor for patients with lung cancer.