PT  - JOURNAL ARTICLE
AU  - Nair, Girija
AU  - Jayalakshmi, T.K.
AU  - Uppe, Abhay
AU  - Iyer, Aparna
AU  - Agrawal, Aditya
TI  - Drug resistance patterns in patients with multi-drug resistant tuberculosis (MDR - TB)
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - P2642
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/P2642.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/P2642.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - Introduction: Incidence of drug resistance to Mycobaterium tuberculosis is increasing with with the emergence of Multi Drug Resistant (MDR) and Extensively Drug Resistant (XDR) strains1.Aim: To study drug resistance patterns in patients with MDR tuberculosis attending the outpatients' clinic at a tertiary care center.Methodology: Sputum of 32 patients, previously diagnosed as MDR tuberculosis was tested for culture and drug sensitivity to first and second line anti-tubercular drugs by Bactec MGIT 960 TB System 2.Results: Resistance patterns obtained.View this table:A high incidence of drug resistance to first line drugs was noted. Amongst the second line drugs, high percentage of resistance to quinolones, cycloserine and ethionamide was observed. 6/32 (18.75%) patients had XDR TB.Conclusion: The study highlights a very high percentage of drug resistance to first and second line anti tubercular drugs amongst patients with MDR TB.References:1. WHO Tuberculosis MDR- TB and XDR -TB 2011, progress report.2. Novel and Improved Technologies for Tuberculosis Diagnosis: Progress and Challenges, Clin Chest Med 30 (2009) 701 - 716.