RT Journal Article SR Electronic T1 Effect of high-flow nasal cannula on nasopharyngeal airway pressure, respiratory muscles loading and respiratory distress symptoms in young infants with severe acute viral bronchiolitis JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P1071 VO 40 IS Suppl 56 A1 Stefan Matecki A1 Christophe Milesie A1 Julien Baleine A1 Aurélien Jacquot A1 Gilles Cambonie YR 2012 UL http://erj.ersjournals.com/content/40/Suppl_56/P1071.abstract AB Objective: To determine the efficacy of high-flow nasal cannula (HFNC) at different flow level on respiratory distress symptoms, nasopharyngeal airway pressure (NAP) and respiratory effort in young infants with acute respiratory syncytial virus bronchiolitis.Patients: 21 less than six month/old infants, with severe respiratory distress.Interventions: Oesophageal pressure (Pes) and NAP was measured simultaneously after 5 different flow of 1,4,6 and 7 l/mn delivered through a HFNC.Measurements and results: Respiratory distress was quantified with a specific scoring system (m-WCAS). Mean respiratory rate (RR), inspiratory time over total time or respiratory cycle (Ti/Tot), NAP, Swing Pes and respiratory effort with the Pes-derived inspiratory muscles pressure-time product (PTPes) was calculated from the pressure curves.Results are presented in Table 1.View this table:Effect HFNC at 1,4,6 and 7 l/mn on respiratory parameters.Conclusion: In young infants with severe acute respiratory syncytial virus bronchiolitis NAP progressively increase with flow delivery through HFNC. We observed a negative correlation between flow delivery, NAP and PTPes. HFNC are able to increase NAP, decrease PTPes and improve ventilatory function of infant with severe acute viral bronchiolitis.Funding by APARD and CHU Montpellier.