TY - JOUR T1 - Bacterial multidrug-resistance profile in a respiratory insufficiency unit - Analysis of 17 months JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P2568 AU - Marisa Anciães AU - Susana Carreira AU - Cecília Nunes AU - Fernanda Oliveira Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P2568.abstract N2 - Introduction: Multidrug-resistant bacteria (MRB) are a seriously growing public health threat.Objectives: Characterize patients with MRB isolations, namely their risk factors. Evaluate frequency of MRB species. Assess influence of antibiotic (AB) therapy towards length of hospital stay (LOS) and mortality.Methods: Retrospective identification of patients with MRB isolations admitted to Respiratory Insufficiency Unit (RIU) from Feb/10 to Jun/11, followed by medical records' analysis.Results: MRB were isolated from 32 patients: male sex — 56.3%; mean age — 74.5 years; chronic respiratory disease — 81.3%; comorbidities — 93.8%, of which 65.6% were immunodepressions. Some (37.5%) were transferred to RIU with an average previous LOS of 42.3 days. At RIU admission 96.9% were/had been on AB and 40.6% had been discharged, in the previous month. 71.9% underwent invasive techniques.There were 44 MRB isolations: MRSA — 45.5%; Acinetobacter baumannii — 29.5%; Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Enterococcus faecium — ≤ 9.1% each. Pathogen directed-AB was introduced in 29 isolates (65.9%), but only 11 (37.9%) underwent post-AB control and only 3 of these (27.3%) became negative.There were 14 (43.8%) deaths, 78.6% due to infectious causes, of which 54.5% were attributed to MRB. We found no statistically significant differences between death and survival groups, however LOS was significantly longer in patients who had >1 isolation and whose post-AB control remained positive.Conclusions: Every patient had at least 1 risk factor for infection. MRSA predominated. MRB were difficult to eradicate and responsible for a high mortality rate. ER -