RT Journal Article
SR Electronic
T1 Targeting EGFR signalling in chronic lung disease: therapeutic challenges and opportunities
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 513
OP 522
DO 10.1183/09031936.00146413
VO 44
IS 2
A1 Sabari Vallath
A1 Robert E. Hynds
A1 Laura Succony
A1 Sam M. Janes
A1 Adam Giangreco
YR 2014
UL http://erj.ersjournals.com/content/44/2/513.abstract
AB Chronic respiratory diseases, including pulmonary fibrosis, chronic obstructive pulmonary disease (COPD) and lung cancer, are the second leading cause of death among Europeans. Despite this, there have been only a few therapeutic advances in these conditions over the past 20 years. In this review we provide evidence that targeting the epidermal growth factor receptor (EGFR) signalling pathway may represent a novel therapeutic panacea for treating chronic lung disease. Using evidence from human patient samples, transgenic animal models, and cell and molecular biology studies we highlight the roles of this signalling pathway in lung development, homeostasis, repair, and disease ontogeny. We identify mechanisms underlying lung EGFR pathway regulation and suggest how targeting these mechanisms using new and existing therapies has the potential to improve future lung cancer, COPD and pulmonary fibrosis patient outcomes. Deregulated EGFR pathway signalling is a common event and an important therapeutic target for many chronic lung diseases http://ow.ly/rH74p