TY - JOUR T1 - Serum lysyl oxidase-like 2 levels and idiopathic pulmonary fibrosis disease progression JF - European Respiratory Journal JO - Eur Respir J SP - 1430 LP - 1438 DO - 10.1183/09031936.00141013 VL - 43 IS - 5 AU - Jason W. Chien AU - Thomas J. Richards AU - Kevin F. Gibson AU - Yingze Zhang AU - Kathleen O. Lindell AU - Lixin Shao AU - Susan K. Lyman AU - Joanne I. Adamkewicz AU - Victoria Smith AU - Naftali Kaminski AU - Thomas O’Riordan Y1 - 2014/05/01 UR - http://erj.ersjournals.com/content/43/5/1430.abstract N2 - We evaluated whether lysyl oxidase-like 2 (LOXL2), which promotes cross-linking of collagen in pathological stroma, was detectable in serum from idiopathic pulmonary fibrosis (IPF) patients, and assessed its relationship with IPF disease progression. Patients from the ARTEMIS-IPF (n=69) and the Genomic and Proteomic Analysis of Disease Progression in IPF (GAP) (n=104) studies were analysed. Baseline serum LOXL2 (sLOXL2) levels were compared with baseline clinical and physiological surrogates of disease severity, and the association with IPF disease progression was assessed using a classification and regression tree (CART) method. sLOXL2 correlated weakly with forced vital capacity and carbon monoxide diffusion capacity (r -0.24–0.05) in both cohorts. CART-determined thresholds were similar: ARTEMIS-IPF 800 pg·mL−1 and GAP 700 pg·mL−1. In ARTEMIS-IPF, higher sLOXL2 (>800 pg·mL−1) was associated with increased risk for disease progression (hazard ratio (HR) 5.41, 95% CI 1.65–17.73). Among GAP subjects with baseline spirometric data (n=70), higher sLOXL2 levels (>700 pg·mL−1) were associated with more disease progression events (HR 1.78, 95% CI 1.01–3.11). Among all GAP subjects, higher sLOXL2 levels were associated with increased risk for mortality (HR 2.28, 95% CI 1.18–4.38). These results suggest that higher sLOXL2 levels are associated with increased risk for IPF disease progression. However, due to multiple limitations, these results require validation. Higher baseline sLOXL2 levels: no correlation with IPF severity, but association with disease progression http://ow.ly/sEbGW ER -