RT Journal Article SR Electronic T1 COPD phenotypes in biomass smoke- versus tobacco smoke-exposed Mexican women JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 725 OP 734 DO 10.1183/09031936.00206112 VO 43 IS 3 A1 Pat G. Camp A1 Alejandra Ramirez-Venegas A1 Raul H. Sansores A1 Luis F. Alva A1 Jill E. McDougall A1 Don D. Sin A1 Peter D. Paré A1 Nestor L. Müller A1 C. Isabela S. Silva A1 Carlos E. Rojas A1 Harvey O. Coxson YR 2014 UL http://erj.ersjournals.com/content/43/3/725.abstract AB We hypothesised that biomass smoke exposure is associated with an airway-predominant chronic obstructive pulmonary disease (COPD) phenotype, while tobacco-related COPD is associated with an emphysema-predominant phenotype. In this cross-sectional study, female never-smokers with COPD and biomass exposure (n=21) and female ex-cigarette smokers with COPD without biomass exposure (n=22) completed computed tomography (CT) at inspiration and expiration, pulmonary function, blood gas, exercise tolerance, and quality of life measures. Two radiologists scored the extent of emphysema and air trapping on CT. Quantitative emphysema severity and distribution and airway wall thickness were calculated using specialised software. Women in the tobacco group had significantly more emphysema than the biomass group (radiologist score 2.3 versus 0.7, p=0.001; emphysema on CT 27% versus 19%, p=0.046; and a larger size of emphysematous spaces, p=0.006). Women in the biomass group had significantly more air trapping than the tobacco group (radiologist score 2.6 and 1.5, respectively; p=0.02) and also scored lower on the symptom, activities and confidence domains of the quality of life assessment and had lower oxygen saturation at rest and during exercise (p<0.05). Biomass smoke exposure is associated with less emphysema but more air trapping than tobacco smoke exposure, suggesting an airway-predominant phenotype. Biomass smoke causes less emphysema but more air trapping than tobacco smoke: airway-predominant COPD phenotype? http://ow.ly/rHdju