PT  - JOURNAL ARTICLE
AU  - Fekri Abroug
AU  - Lamia Ouanes-Besbes
AU  - Mohamed Fkih-Hassen
AU  - Islem Ouanes
AU  - Samia Ayed
AU  - Fahmi Dachraoui
AU  - Laurent Brochard
AU  - Souheil ElAtrous
TI  - Prednisone in COPD exacerbation requiring ventilatory support: an open-label randomised evaluation
AID  - 10.1183/09031936.00002913
DP  - 2014 Mar 01
TA  - European Respiratory Journal
PG  - 717--724
VI  - 43
IP  - 3
4099  - http://erj.ersjournals.com/content/43/3/717.short
4100  - http://erj.ersjournals.com/content/43/3/717.full
SO  - Eur Respir J2014 Mar 01; 43
AB  - Recommendation of the use of systemic steroids in chronic obstructive disease (COPD) exacerbation rely on trials that excluded patients requiring ventilatory support. In an open-label, randomised evaluation of oral prednisone administration, 217 patients with acute COPD exacerbation requiring ventilatory support were randomised (with stratification on the type of ventilation) to usual care (n=106) or to receive a daily dose of prednisone (1 mg·kg−1) for up to 10 days (n=111). There was no difference regarding the primary end-point, intensive care unit mortality, which was 17 (15.3%) deaths versus 15 (14%) deaths in the steroid-treated and control groups, respectively (relative risk 1.08, 95% CI 0.6–2.05). Analysis according to ventilation modalities showed similar mortality rates. Noninvasive ventilation failed in 15.7% and 12.7% (relative risk 1.25, 95% CI 0.56–2.8; p=0.59), respectively. Both study groups had similar median mechanical ventilation duration and intensive care unit length of stay, which were 6 (interquartile range 6–12) days versus 6 (3.8–12) days and 9 (6–14) days versus 8 (6–14) days, respectively. Hyperglycaemic episodes requiring initiation or alteration of current insulin doses occurred in 55 (49.5%) patients versus 35 (33%) patients in the prednisone and control groups, respectively (relative risk 1.5, 95% CI 1.08–2.08; p=0.015). Prednisone did not improve intensive care unit mortality or patient-centred outcomes in the selected subgroup of COPD patients with severe exacerbation but significantly increased the risk of hyperglycaemia. In COPD exacerbation needing ventilatory support, prednisone has no impact on ICU mortality or related patient outcome http://ow.ly/qxGq0