RT Journal Article
SR Electronic
T1 Prior cardiovascular disease increases long-term mortality in COPD patients with pneumonia
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 36
OP 42
DO 10.1183/09031936.00117312
VO 43
IS 1
A1 Sibila, Oriol
A1 Mortensen, Eric M.
A1 Anzueto, Antonio
A1 Laserna, Elena
A1 Restrepo, Marcos I.
YR 2014
UL http://erj.ersjournals.com/content/43/1/36.abstract
AB There is controversy regarding the impact of chronic obstructive pulmonary disease (COPD) in clinical outcomes in elderly patients with pneumonia. Comorbidities such as cardiovascular disease have been reported to play an important role in patients with acute exacerbations of COPD. However, limited data are available regarding the impact of cardiovascular disease in elderly COPD patients who require hospitalisation for pneumonia. We examined a cohort of subjects with pneumonia and pre-existing COPD. Prior cardiovascular disease was defined as history of myocardial infarction, congestive heart failure, cardiac arrhythmia, unstable angina or stroke. Outcomes examined included 30-day, 90-day, 6-month and 1-year mortality. We included 17 140 elderly COPD patients who were hospitalised for pneumonia. Prior cardiovascular disease was present in 10 240 (59.7%) patients. Prior cardiovascular disease was independently associated with 90-day mortality (21.3% versus 19.4%; hazard ratio (HR) 1.29, 95% CI 1.02–1.17), 6-month mortality (29.0% versus 26.1%; HR 1.28, 95% CI 1.07–1.50) and 12-month mortality (39.2% versus 34.5%; HR 1.33, 95% CI 1.15–1.54) when compared to no prior cardiovascular disease. The temporal differential effect between groups increases from 1.0% at 30 days to 4.7% at 1 year. Prior cardiovascular disease is associated with increased long-term mortality in elderly COPD patients with pneumonia. Differences in mortality rates increased over time. Prior cardiovascular disease is associated with increased long-term mortality in elderly COPD patients with pneumonia http://ow.ly/qaAJY