RT Journal Article
SR Electronic
T1 Association between sleep disordered breathing and aggressiveness markers of malignant cutaneous melanoma
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1661
OP 1668
DO 10.1183/09031936.00115413
VO 43
IS 6
A1 Miguel-Ángel Martínez-García
A1 Antonio Martorell-Calatayud
A1 Eduardo Nagore
A1 Irene Valero
A1 Maria Jose Selma
A1 Eusebi Chiner
A1 Pedro Landete
A1 Josep-Maria Montserrat
A1 Cristina Carrera
A1 Amalia Pérez-Gil
A1 Francisco Campos-Rodríguez
A1 Ramón Farré
YR 2014
UL http://erj.ersjournals.com/content/43/6/1661.abstract
AB Some recent studies have shown an association between sleep disordered breathing (SDB) and cancer mortality and incidence but no study has focused on a specific type of cancer. The objective of this study was to analyse the relationship between the severity of SDB and factors related to cutaneous malignant melanoma (CMM) aggressiveness. We performed a multicentre observational study in 82 consecutive patients diagnosed with CMM. 56 patients in whom melanoma measurements were available were finally included in the study. Melanoma measurements of aggressiveness included: tumour mitotic rate, Breslow index, presence of ulceration, stage of disease and growth rate of melanoma. A sleep study was performed in all the included patients. Multivariate analyses were used to examine the independent relationship between SDB severity (apnoea–hypopnea index (AHI) and nocturnal oxygen desaturation indexes (ODI3% and ODI4%)) and measures of CMM aggressiveness. 60.7% of patients had SDB (AHI ≥5) and 14.3% severe obstructive sleep apnoea (AHI ≥30). In fully adjusted multivariate analyses, AHI (OR 1.08, 95% CI 1.02–1.14), ODI3% (OR 1.08, 95% CI 1.02–1.11) and ODI4% (OR 1.1, 95% CI 1.02–1.2) were independently associated with an increased melanoma growth rate. Furthermore, AHI, ODI4% and ODI3% were significantly correlated with other aggressiveness factors of CMM, such as Breslow index, presence of ulceration and mitotic index. SDB severity markers are associated with some aggressiveness markers of CMM. This study adds evidence on the relationship between sleep disordered breathing and cancer aggressiveness http://ow.ly/tMRYu