PT  - JOURNAL ARTICLE
AU  - Sigsgaard, Torben
AU  - Bolund, Anneli C.S.
AU  - Basinas, Ioannis
AU  - Elholm, Grethe
AU  - Omland, Øyvind
AU  - Miller, Martin
AU  - Schlünssen, Vivi
TI  - Alpha-1-antitrypsin phenotype and endotoxin exposure are related to BHR but not to change in lung function in a 15 year follow up of young Danish farmers
DP  - 2013 Sep 01
TA  - European Respiratory Journal
PG  - P1398
VI  - 42
IP  - Suppl 57
4099  - http://erj.ersjournals.com/content/42/Suppl_57/P1398.short
4100  - http://erj.ersjournals.com/content/42/Suppl_57/P1398.full
SO  - Eur Respir J2013 Sep 01; 42
AB  - We have earlier shown that farming exposure interacs with rare Alpha-1-antitrypsin (α1-AT) phenotypes in relation to BHR*. We studied 1,964 farming students and 407 controls in 1992/4, and 963 and 172 of these again in 2007/8. Spirometry, a health questionnaire, smoking and occupational history were collected each time. Cumulative dust and endotoxin exposures were estimated from job-exposure matrices based on personal dust measurements. Lung function change was expressed as Δz-scores using the LMS equations (Stanojevic S, et al. AJRCCM 2008; 177: 253-60). We also studied bronchial hyperresponsiveness using the Yan method with Metacholine. People with an α1-AT serum concentration <22 mM were tested for phenotype. For subsequent analyses, the different α1-AT Pi-groups were collapsed into three groups: 1) MM & MX; 2) MS & MZ; 3) SZ, SS, ZZ.Table 1 shows the OR (95% c.i.) for BHR at follow up according to Pi-group, endotoxin exposure and smoking in the cohort.It can be seen, that all three variables were significantly associated to an increased OR for BHR. This confirms our earlier finding in the cohort. However we were not able to show any significant interaction between Pi-types and exposure. No effect of the Pi types were found on lung function change, neither for FEV1 nor for FVC.View this table:The association between alfa-1-antitrypsin Endotoxin and BHR*Sigsgaard et al ERJ 2000.