RT Journal Article
SR Electronic
T1 The effects of bacilli Calmette Guerin-polysaccharide nucleic acid on nasal airway inflammation and resistance in allergic rhinitis mice
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p973
VO 38
IS Suppl 55
A1 Yin Xi
A1 Kefang Lai
A1 Lina Han
A1 Na Wu
A1 Yanhua Hong
A1 Jiaxing Xie
A1 Wei Luo
A1 Nanshan Zhong
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p973.abstract
AB Background: Lots of data can be found to approve that exposure to mycobacteria has the potential to suppress the development of allergic rhinitis or atopy.But the influence of bacilli Calmette Guerin-polysaccharide nucleic acid (BCG-PSN) especially on nasal airway inflammation and resistance (RNA) on mice,are poorly understood.Objective: Investigate the effects of BCG-PSN on nasal airway inflammation and resistance in allergic rhinitis mice.Method: Balb/c mice were sensitized by intraperitoneal injection of ovalbumin (OVA)/saline,then challenged by intranasal administration under conscious to establish an allergic rhinitis model.The mice were intervened with BCG-PSN by intranasal administration (1, 5, 10μg) before sensitization. A novel method of RNA was applied to measure nasal function. Then the inflammation of nose was accessed by nasal tissues histology.Result: In 3 interventions groups the RNA had no statistical difference compared to rhinitis group.But compared to the normal group,the RNA of expiration in 10μg,5μg group and the RNA of inspiration in 10μg group had no statistical difference.The number of eosinophils (Eos) in 10μg group was lower than rhinitis group as well as mucosal thickness.Conclusion: BCG-PSN can inhibit nasal airway inflammation and decrease nasal airway resistance in allergic rhinitis mice.