TY - JOUR T1 - Polymorphism of glutation-S-transferases T1 and M1 in chronic obstructive pulmonary disease JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p706 AU - Svetlana Vakhrusheva AU - Vera Nevzorova AU - Tatyana Tilik AU - Evgeny Gilifanov AU - Marina Issaeva AU - Elena Samoilenko Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p706.abstract N2 - Chronic obstructive pulmonary disease (COPD) is the result of genetic factors and environmental conditions influence on a human organism. Glutation-S-transferases (GST) play significant role in cell resistance to oxidative stress, and in prevention of DNA damage from products of tobacco smoke.80 patients have been examined. They were divided into two groups: 1 group - smoking persons without COPD; 2 group – smoking patients with I or II stages of COPD (2 subgroups). The control group consisted of healthy non-smoking persons.In control group homozygous deletion of GSTT1 was found in 5% of patients. GSTT1 null-genotype has been revealed in 14.3% in first group and in 17.6% of cases in second group. Reliability of distinctions between groups was not received. However in comparison of the control group with subgroups of COPD patients statistically significant difference between frequency of GSTT1 null-genotype in control group and in II stage COPD patients had been received (χ2 =10, p=0.02).For smoking persons without COPD and patients with I stage of COPD OR equaled 1, and for smoking persons and II stage COPD patients OR was 1.5 that indicated on increased risk of illness with severe stage of COPD at presence of GSTT1 null-genotype. Also OR, identical to smokers without COPD and patients with COPD stage I, means equal risk of disease that was especially significant for smokers without COPD.Frequency of GSTM1 null-genotype in all groups was equal (46.6, 46.4, 47% accordingly).The results of our research demonstrate that null-genotype of GSTT1 could be recommended as a marker of chronic obstructive pulmonary disease fast progressing in smokers. ER -