RT Journal Article SR Electronic T1 Occupational exposures and uncontrolled adult-onset asthma in the European Community Respiratory Health Survey II JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 374 OP 386 DO 10.1183/09031936.00034913 VO 43 IS 2 A1 Nicole Le Moual A1 Anne-Elie Carsin A1 Valérie Siroux A1 Katja Radon A1 Dan Norback A1 Kjell Torén A1 Mario Olivieri A1 Isabel Urrutia A1 Lucia Cazzoletti A1 Bénédicte Jacquemin A1 Geza Benke A1 Hans Kromhout A1 Maria C. Mirabelli A1 Amar J. Mehta A1 Vivi Schlünssen A1 Torben Sigsgaard A1 Paul D. Blanc A1 Manolis Kogevinas A1 Josep M. Antó A1 Jan-Paul Zock YR 2014 UL http://erj.ersjournals.com/content/43/2/374.abstract AB Occupational exposure is a well-recognised modifiable risk factor for asthma, but the relationship between occupational exposure and asthma control has not been studied. We aimed to study this association among working-age adults from the European Community Respiratory Health Survey (ECRHS). Data were available for 7077 participants (mean age 43 years, 45% never-smokers, 5867 without asthma and 1210 with current asthma). Associations between occupational exposure to specific asthmagens and asthma control status (33% with uncontrolled asthma, based on the Global Initiative for Asthma guidelines) were evaluated using logistic and multinomial regressions, adjusted for age, sex and smoking status, with study areas included as a random effect. Statistically significant positive associations were observed between uncontrolled adult-onset asthma and both past 12-month and 10-year exposure to any occupational asthmagens (OR (95% CI) 1.6 (1.0–2.40) and 1.7 (1.2–2.5), respectively); high (1.7 (1.0–2.8) and 1.9 (1.3–2.9), respectively) and low (1.6 (1.0–2.7) and 1.8 (1.2–2.7), respectively) molecular weight agents; and cleaning agents (2.0 (1.1–3.6) and 2.3 (1.4–3.6), respectively), with stronger associations for long-term exposures. These associations were mainly explained by the exacerbation domain of asthma control and no associations were observed between asthmagens and partly controlled asthma. These findings suggest that occupational exposure to asthmagens is associated with uncontrolled adult-onset asthma. Occupational risk factors should be quickly identified to prevent uncontrolled asthma. Occupational exposure to asthmagens is associated with uncontrolled adult-onset asthma in ECRHS II http://ow.ly/reN8g