@article {Cuttsp3281, author = {Rebecca Cutts and Steve Turner}, title = {The relationship between exhaled nitric oxide measurements and subsequent asthma control in a cohort of children followed over 12-months}, volume = {38}, number = {Suppl 55}, elocation-id = {p3281}, year = {2011}, publisher = {European Respiratory Society}, abstract = {Introduction: Exhaled nitric oxide (FENO) may be a useful biomarker for childhood asthma control but clinical studies have been disappointing. The aims of the present observational study was to relate FENO values with later asthma control and to derive clinically useful FENO cut off values.Methods: Children with stable asthma were recruited. Exhaled NO was measured at two month intervals when the Childhood Asthma Control Test (CACT) was also completed.Results: Forty nine children with stable asthma were recruited in whom 252 FENO measurements were made. Exhaled NO was inversely related to CACT after two months (rho -0.22, p=0.005, n=158) and four months (rho -0.23, p=0.009, n=127) but not six months (rho -0.12, p=0.256, n=93). There were 121 2-month periods when asthma remained well controlled (mean initial FENO 20.9ppb [95\%CI 17.6, 23.5]), 12 when control was gained (35.0ppb [22.1, 55.3]), 8 when good control was lost (28.3ppb [12.4, 64.7]) and 15 when control remained poor (19.0ppb [95\%CI 13.2, 27.4]); the difference in FENO between remain controlled and became controlled was significant (p=0.022). Exhaled NO of \>46ppb had sensitivity of 63\% and specificity of 77\% for predicting future loss of asthma control (AUC 0.61). Exhaled NO of \>22ppb had a sensitivity of 65\% and specificity of 58\% for a future reduction in CACT of 3 points (AUC 0.65).Conclusions: Increased FENO is associated with reduced asthma control over the following four months. In this population of stable asthmatic children, increased FENO lacked precision for predicting future changes in asthma control. Exhaled NO might be useful in predicting ongoing well-controlled asthma.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/38/Suppl_55/p3281}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }