PT  - JOURNAL ARTICLE
AU  - Jiefeng Xi
AU  - Xingde Li
AU  - MingYing Zeng
AU  - Sheng Xu
AU  - Rex Yung
TI  - Transbronchoscopic 3D volumetric optical coherence tomography (OCT) imaging of airways
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p3719
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p3719.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p3719.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Introduction: OCT, a non-invasive optical modality capable of high-resolution cross-sectional imaging of tissue microanatomy, holds potential of “in-vivo” diagnostics of pathology. Development of miniature probes & laser sources have advanced real-time OCT imaging of small structure such as airway morphologies.Aim: To develop 3D volumetric OCT imaging of airways.Methods: IRB approved porcine protocol. Airways imaged with a 1300-nm swept-source OCT at a 40 kHz A-scan rate, placed within a1.3 mm catheter advanced through 2 mm bronchoscope channel. Axial & lateral resolution of the system is ∼7 μm and ∼20 μm in tissue, respectively. 3D volumetric imaging achieved by rotating the OCT catheter while pulling it back (similar to spiral CT), at an imaging speed of 10 frames/sec & helical rotation pitch of ∼100 μm.Results: 3rd to 7th generation airways imaged, spiral scanning data recorded, then processed. In addition to presentation as isolated axial slices, playback can present spiral imaging reformatted as 3D volumes plus virtual fly-through of airways.Conclusion/Clinical significance: Transbronchoscopic OCT imaging can generate high-res axial imaging of airway microstructures. Reconstruction of dataset generates dynamic 3D imaging. In-vivo temporal monitoring of pathologic events such as cancer progression or physiologic effects of bronchoconstriction in airway disease will advance diagnosis and management of lung diseases.