RT Journal Article
SR Electronic
T1 Immune status in patients with bronchial asthma exacerbation and comorbide digestive system diseases
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p3845
VO 38
IS Suppl 55
A1 Shamil Zagidullin
A1 Elena Galimova
A1 Guzel Nurtdinova
A1 Rustem Zulkarneev
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p3845.abstract
AB Bronchial asthma (BA) is frequently linked with digestive system pathologyAim: To evaluate features of immune status in bronchial asthma (BA) patients with and without comorbide digestive system diseases (DSD).Materials and methods: Prospective, descriptive study of 90 hospitalized patients with bronchial asthma exacerbation and 31 healthy controls. Immune status was assessed via quantitation of lymphocytes subpopulations, immunoglobulins A,E,G,M, circulating immune complexes. Digestive system diseases were diagnosed via gastroscopy and ultrasonic scanning.Results: 61 (67,8%) patients with BA exacerbation suffered from digestive system diseases:gastritis, duodenitis-27 patients (30,0%), duodenum anabrosis-4 (4,5%), gastric-duodenum reflux-20 (22,2%), biliary dyskinesia-10 (11,1%).Immune response parameters were decreased in both groups of BA patients vs. controls.View this table:Immune status in patients with BA±DSDPatients with BA and DSD showed significant decrease of CD4, CD8 and IgA vs. controls and patients with BA without comorbidities.Conclusions: Comorbide digestive system diseases in patients with BA are associated with significant decrease of activity of cell and humoral parts of immune system.