PT  - JOURNAL ARTICLE
AU  - Rabab El Wahsh
AU  - Ali Zaki
TI  - Pleuro-pulmonary changes in patients suffering from end-stage renal disease receiving regular hemodialysis
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p3617
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p3617.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p3617.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Introduction: End-stage renal disease (ESRD) was defined as a life-threatening reduction in glomerular filtration rate resulting in the requirement for hemodialysis, peritoneal dialysis or renal transplantation to maintain life. Pulmonary complications are an important cause of morbidity and mortality in patients with ESRD and infection is the second leading cause of death among them.Aim: To study pleuro-pulmonary changes and complications among patients with ESRD maintained on regular hemodialysis.Patients and methods: The current study included 20 patients with ESRD on regular hemodialysis for at least 6 months. For every patient, clinical, laboratory, arterial blood gases, radiological study of chest and heart and spirometric study were done.Results: Among the studied patients, 55% had pulmonary complications in the form of pulmonary infections, pleural effusion, pulmonary edema or hypoxemia during the course of hemodialysis. Spirometric measures, before and after hemodialysis, showed no significant improvement of VC, FVC, FEV1/FVC or MMV, whereas improvement in FEF25-75% and PEFR was significant. Significant hypoxemia occurred during hemodialysis. Significant improvement in pH, paCO2 and HCO3 occurred during and after hemodialysis.Conclusion: Patients with ESRD treated with hemodialysis must be considered at high risk for the development of lethal pulmonary complications. Regular hemodialysis improves arterial blood gases parameters and some pulmonary function measurements.