RT Journal Article
SR Electronic
T1 The particularities of pulmonary tuberculosis (TB)-diabetus mellitus (DM) syntropy in a community with high prevalence for TB
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p2595
VO 38
IS Suppl 55
A1 Ghiulten Apti
A1 Anamaria Trailescu
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p2595.abstract
AB It is well known that patients with DM had a greater risk for TB. Our city is known with one of the highest prevalence of TB in our country. Aim to investigate the features of TB-DM syntropy;We made a case control epidemiologic study - on 292 patients hospitalized between 2005-2009; we enrolled 146 patients diagnosed with new case-TB (group 1) and 146 patients with TB and DM (group 2);data were collected by reviewing the medical records of hospitalized patients.Results: In group 2 DM was diagnosed after TB in 24%;TB occurred after an average period of 5,5 years in those with previous DM;DM had type 1 in 34% and type 2 insulin necessitant 50,1%; in both groups predominated insidious onset; hemoptysia was more frequent in TB lot and fever and malaise in DM-TB; in 6% onset was with diabetic coma. Radiological pattern:in group 2 predominated bilateral infiltrates (extensive form) and atypical localization (lower lobs);pleurisy and cavitation were frequent in group 1; bacteriological exam 74% smear positive in group 2 and 71% in group 1;the rate of negativity under treatment was slower in lot 2: 37% still positive after 2 months, and 7% after 3 months; complications under treatment occurred more frequent in group 2 (hepatitis and hematologic changes);costs with medication and hospitalization (average: 78±16days) were greater in group 2 (about three fold); early relapses occurred only in 3,9% in group 2 and 9,2% in group 1 (p=0,001).Conclusions: DM represent a risk for TB; Time between onset of DM and TB was shorter than in literature. in DM patients disease is more extensive with slower healing and high percent of complication during treatment than those without DM.