TY - JOUR T1 - Plasma vitamin D concentration and clinical characteristics in clinically stable patients with moderate COPD JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p4742 AU - Elisabeth Romme AU - Lidwien Graat-Verboom AU - Erica Rutten AU - Frank Smeenk AU - Martijn Spruit AU - Emiel Wouters Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p4742.abstract N2 - Introduction: Vitamin D deficiency is associated with poor functional performance in patients with COPD. However, most research is limited to patients with severe COPD, whilst vitamin D deficiency also occurs in GOLD stage II patients (Janssens et al. Thorax 2010). Therefore, we aimed to investigate differences in clinical characteristics in clinically stable GOLD stage II patients with and without vitamin D deficiency.Methods: 159 patients with COPD GOLD stage II (age 69±9 yrs; FEV1 65±9% pred; 58% men) recruited at the outpatient consultation office of the Catharina Hospital were included. Vitamin D deficiency was defined as plasma 25(OH)D concentration <50 nmol/L. BMI, FEV1, RV/TLC, arterial pO2, MRC dyspnea, six-minute walk distance (6MWD) and score on the BODE index were assessed. The number of sunshine hours 2 months before blood sampling was determined using data from the Royal Netherlands Meteorological Institute.Results: Vitamin D deficient patients had higher RV/TLC, lower pO2, worse 6MWD, higher BODE score and less sunshine hours.View this table:After correction for confounders, vitamin D deficiency was associated with lower pO2, higher BODE score and less sunshine hours (all p≤0.03).Conclusions: Vitamin D deficiency is common in COPD GOLD stage II patients. Moreover, patients with vitamin D deficiency were characterized by lower arterial pO2, worse exercise performance and higher BODE score. ER -