RT Journal Article
SR Electronic
T1 Vitamin-D supplementation in patients with new smear positive pulmonary tuberculosis (PTB) with refrence to sputum conversion
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p2588
VO 38
IS Suppl 55
A1 Srivastava, Govind Narayan
A1 Chaudhry, Sandeep
A1 Kumar, Hemant
A1 Singh, S.K.
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p2588.abstract
AB Back ground: PTB is major problem in developing countries like india. Role of vit-D as immunomodulator which also suppresses growth of mycobacterial bacilli in macrophages, helps in treatment of PTB and early sputum conversion.Methods: Study includes 60 patients of sputum positive PTB above age of 15 yrs with sex ratio 1:0.7, from may 2009 to October 2009 to avoid seasonal variation. All patients were divided in to 2 groups randomly. one group (28 patients) received only ATT and other group (32 patients) received ATT with oral cholecalciferol (vit d) 60,000 IU daily for 5 days. serum vit D were measured pretreatment and at every 2 weeks for 8 weeks. other measurements like sputum smear for AFB, Hb etc also measured.data were analysed.Results: There is significant increase in Hb at 8 weeks (P-0.03), Decrease in mean ESR at 8th week (P-0.0001) and increase in weight gain after 8 weeks (P-0.0312) in group who received vit D along with ATT.View this table:Table 1There was early sputum conversion in patient who received vit D and ATT but this difference was not significant stastically so further study with large sample is required.View this table:Table 2Conclusion: Supplementation with vit D in patients with smear positive PTB was of benefit in terms of haemoglobin, weight gain, ESR reduction and general well being. An early sputum conversion was observed in patients who received vit D supplementation.