TY - JOUR T1 - Bone mineral density in patients with COPD depending on pulmonary function parameters JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p3595 AU - Olga Kharevich AU - Irina Lapteva AU - Artem Tomashevsky AU - Natalia Porahonko AU - Natalia Vasilieva AU - Volha Vadzianava Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p3595.abstract N2 - Introduction: Osteoporosis is one of the most serious systemic effects of chronic obstructive pulmonary disease (COPD), which has serious consequences and significant impact on mortality, social and economic burden.Aims and objectives: The aim of the study was to investigate the relations between pulmonary function parameters and bone mineral density (BMD) in patients with COPD.Methods: In the recent research we have studied data of pulmonary function tests (by spirometry, bodyplethysmography, diffusing lung capacity) and BMD measurements by dual-energy X-ray absorptiometry in 24 patients with COPD. To compare BMD values in patients with FEV1< 50% and those with FEV1>50%, we used the Mann-Whitney test. Correlations were estimated by Spearman coefficient. Data are presented as median (interquartile range).Results: There were significant differences between BMD values (T-score) in patients with FEV1<50% (n=14, female-1, males-13, median age 56,5 [51; 61]) and those with FEV1>50% (n=10, females-3, males-7, median age 56,0 [54; 58]) in lumbar spine (-1,7 [-2,4; 0,3] versus -0,3 [-0,6; 1,0], p=0,04) and in femoral neck (-1,7 [-2,6; -0,4] versus -0,5 [-0,7; -0,3], p=0,043). Correlation analysis revealed relations between BMD values and residual lung volume (Neck: r = -0,808, p = 0,005; Upper Neck: r = -0,697, p = 0,025; Total: r = -0,683, p = 0,029), ratio of residual lung volume to total lung capacity (Neck: r = -0,722, p = 0,018), diffusing lung capacity (Neck: r = 0,597, p = 0,039).Conclusion: The results of the study confirm the role of lung function reduction in bone loss and osteoporosis development in patients with COPD. ER -