RT Journal Article
SR Electronic
T1 Influence of the initial venous thrombo-embolism event on outcome in patients with COPD: Findings from the RIETE registry
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p3950
VO 38
IS Suppl 55
A1 Laurent Bertoletti
A1 Sara Quenet
A1 Silvy Laporte
A1 Luis Hernandez
A1 Juan José Martin-Villasclaras
A1 Carlos Tolosa
A1 Mariano Valdes
A1 Manuel Barron
A1 José Todoli
A1 Manuel Monreal
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p3950.abstract
AB Background: We recently found that COPD patients present more frequently with Pulmonary Embolism (PE) than Deep Venous Thrombosis (DVT) but also experience more death, PE and bleeding during a 3-month follow-up, than non-COPD patients.Aims: To assess whether the 3-month outcomes of VTE patients with COPD depend on the initial VTE presentation, in the RIETE registry.Method: We used a logistic regression to assess the association between the initial VTE presentation and the 3-month risk of death, bleeding and PE occurrence. Potential confounding factors were considered.Results: 1761 (59%) of the 2984 COPD patients presented initially with PE. They were more frequently older and female, and less frequently obese or with a history of VTE than COPD patients with DVT. The 3-month cumulative incidence of symptomatic PE, death and major bleeding were respectively 1.5% (95%CI [1.1% - 1.9%]), 10.8% [2.1% - 3.2%] and 2.6% [9.7% - 11.9%]. Factors associated with these outcomes are presented in Table 1.View this table:Conclusions: COPD patients initially presenting with PE are at a 3-month higher risk of death and major bleeding. Whether more efficient treatments without any increased bleeding risk (as filter) could improve their prognostic deserves further research.