TY - JOUR T1 - Could platelet-activating factor acetylhydrolase (PAF-AH) predict adverse event in pulmonary hypertension? JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p3331 AU - Rozenn Quarck AU - Hervé Durand AU - Ewa Ninio AU - Marion Delcroix Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p3331.abstract N2 - Chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH) are threatened conditions mostly diagnosed at late stages. Inflammation could play a role in the pathogenesis. The need of new biomarkers, non-invasively measurable may help to improve the diagnosis and follow up. PAF-AH, a plasmatic enzyme, is a predictive risk factor for cardiovascular events.In a prospective study, we have investigated a potential role of PAF-AH in predicting the outcome in PAH and CTEPH. Circulating PAF-AH activity has been measured in consecutive patients diagnosed with PAH (n=152) and CTEPH (n=115), at the time of right heart catheterization and compared to a control group of healthy subjects (n=115).Circulating PAF-AH activity was lower in CTEPH and PAH patients compared to controls (37, 95% CI: 33-41; 41, 95% CI: 37-45; 54, 95% CI: 50-60 nmol.mL-1.min; p<0.0001). In PAH, PAF-AH activity is correlated to total cholesterol (r=0.29, p=0.0002) and to LDL-cholesterol (r=0.26, p=0.001). In CTEPH, PAF-AH activity is correlated to pulmonary vascular resistance (PVR; r=0.21, p=0.02) and to LDL-cholesterol (r=0.22, p=0.01). In PAH, clinical worsening is associated with an elevated PAF-AH activity (36, 95% CI: 32-41 vs. 45, 95% CI: 40-51; p=0.04). PAH patients with a mean pulmonary arterial pressure>50 mmHg, and with CRP>4mg.L-1 have increased PAF-AH activity (35, 95% CI: 30-41 vs. 47, 95% CI: 43-52; p=0.02 - 37, 95% CI: 32-42 vs. 45, 95% CI: 40-51; p=0.02, respectively). Non-operable CTEPH patients with PAF-AH activity>50 nmol.mL-1.min have a better survival (p=0.02).Our results suggest that PAF-AH could be a prognostic factor in pulmonary hypertension. ER -