TY - JOUR T1 - The prognostic significance of cardiopulmonary exercise in IPF JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p659 AU - Christina Triantafillidou AU - Panagiotis Lyberopoulos AU - Likourgos Kolilekas AU - Konstantinos Kagouridis AU - Sotirios Gyftopoulos AU - Christina Sotiropoulou AU - Anastasia Kotanidou AU - Anna Karakatsani AU - Spyros Papiris Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p659.abstract N2 - Background: In Idiopathic Pulmonary Fibrosis parenchymal lung damage leads to defects in mechanics and gas exchange, manifesting with progressive dyspnea and exercise limitation. Since IPF carries a poor prognosis, early and reliable prediction of survival is of significant value to the clinician. The role of maximal exercise data in prognostic evaluation of IPF patients is uncertain.Aims and objectives: The aim of the present study was to evaluate the prognostic significance of cardiopulmonary exercise test (CPET) in this group of patients.Methods: Twenty five IPF patients were prospectively recruited and underwent functional evaluation through maximal (CPET) and submaximal exercise testing (6 minute walk test- 6MWT) at diagnosis. Patients were followed up regularly; epidemiologic and survival data were gathered. Correlations between survival and parameters of maximal and submaximal exercise were calculated.Results: Mean survival was 44.4 months.Statistically significant correlations were found between survival and CPET parameters such as VO2peak (p=0.02, RR=0.99), VO2peak/kg (p=0.01, R=0.78), AT (p=0.01, RR=0.72), SpO2peak (p=0.01, RR=0.8), VE/VCO2slope (p=0.005, RR=1.09), VE/VCO2AT (p=0.008, RR=1.14) and the 6MWT parameters: distance walked (p=0.008, RR=0.99) and desaturation (p=0.01, RR=1.42).Conclusions: Physiological parameters obtained during maximal and submaximal exercise testing reflect survival in IPF population. ER -