RT Journal Article
SR Electronic
T1 Reference data transition of whole-body plethysmography from infancy to childhood
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p2021
VO 38
IS Suppl 55
A1 Richard Kraemer
A1 Aida Mashkouri Najafi
A1 Ernst Stadlober
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p2021.abstract
AB Rationale: Advances in plethysmographic measurement techniques have made it possible to obtain lung function data in infants [1] and children. However, application remains limited by the lack of appropriate transitional normative data from infancy to childhood, especially for effective specific airway resistance (sReff).Objectives: On previously collected lung function data, updated prediction equations were modeled spanning from infant's years to childhood, using the LMS method.Methods: Normative lung function data from 67 healthy young infants aged 2.3 to 28.2 (10.8±6.3) months and children aged 5.1 to 16.8 (10.4±2.9) years were evaluated, and prediction equations for functional residual capacity (FRCpleth), and sReff were computed. Applying the LMS method in R environment using GAMLSS package [2] the changing distribution of the measurements is summarized by three curves representing the median (M), coefficient of variation (S) and skewness (L) in relation to age.Results: The present prediction equations feature the first attempt to provide continuous normative data of infants with a smooth transition into childhood (Table 1).View this table:Table 1Conclusions: Updated prediction equations of plethysmographic data for infants and children applying LMS statistics provide a new basis for longitudinal evaluation of lung function in children with lung disease.References:1. Respiration 1993, 60:1-8.2. Statistics in Medicine 2004, 23:3053-3076.