TY - JOUR T1 - The expression and clinical significance of PD-L1<sup>+</sup>CD68<sup>+</sup> macrophages in peripheral blood mononuclear cells of non-small cell lung cancer JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p2796 AU - Jian An Huang AU - Yan Bin Chen AU - Ping Xu Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p2796.abstract N2 - Purpose: To explore the roles of PD-L1+ (programmed death-1-ligand 1) CD68+ macrophages in peripheral blood mononuclear cells (PBMCs) of non-small cell lung cancer (NSCLC) by flow cytometry (FCM).Materials and methods: 60 squamous cell carcinoma patients, 60 adenocarcinoma patients and 60 healthy controls were recruited in the study. PD-L1+CD68+ macrophages were isolated from PBMCs of the 180 persons with FCM.Results: Squamous cell carcinoma and adenocarcinoma group had higher PD-L1+CD68+ macrophages expression compared to healthy controls (P&lt;0.001 and P=0.013 respectively), and PD-L1+CD68+ macrophages from squamous cell carcinoma were higher than that from adenocarcinoma group [(19.03±12.28)% vs (14.21±11.88)%, P = 0.031)].Conclusions: PD-L1+CD68+ macrophages in PBMCs have marked relationship with squamous cell carcinoma and adenocarcinoma, especially can produce profound effect on squamous cell carcinoma. ER -