TY - JOUR T1 - One year follow-up of intrabronchial lung volume reduction in alpha-1-antitrypsin deficiency and severe emphysema JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p3538 AU - Gunnar Hillerdal AU - Stephanie Mindus Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p3538.abstract N2 - Introduction: In patients with alpha-1-antitrypsin (AAT) deficiency, severe emphysema mainly localized to the lower lobes can develop. Volume reduction surgery (LVRS) is not recommended in these patients.Objectives: One-way valves in selected bronchi can reduce the size of hyper-inflated lung areas, and we decided to make a pilot study of intra-bronchial volume reduction (IBVR) in patients with AAT deficiency and severe lower lobe disease.Methods: In patients aged 40-80 years, with RV >150% and FEV1sec 15-45% of predicted, and predominantly lower lobe disease, IBRV with installation of 3-4 valves in one selected lower lobe was performed.Results: Five patients were included. There were no complications. An immediate improvement, both subjectively and objectively, occurred and remained during the six months the patients have been followed. FEV1sec increased from a mean of 0.76 to 1.2 L (57%) and RV decreased from 5.7 L to 4 L (42%).Conclusion: IBRV seems to be a safe, reversible, and simple method to improve lung function in selected patients with AAT deficiency. Further studies are warranted. ER -