RT Journal Article
SR Electronic
T1 Investigating of CEA, CA125, CA15-3, CA19-9, fT3, fT4, TSH, vitamin B12, folic acid and ferritin in malignant and benign diseases due to enviromental asbestos exposure
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p1068
VO 38
IS Suppl 55
A1 Isa Döngel
A1 Mehmet Bayram
A1 Semsettin Sahin
A1 Ismail Benli
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p1068.abstract
AB Aim: To identify several biochemical marker levels in mesothelioma (MM), in subjects with pleural plaques (PP) due to environmental asbestos exposure (EAE) and in healthy subjects with EAE.Method: 277 patients with PP from villages close to ophiolitic units (OU) (serpentin asbest containing), 121 healthy subjects from villages close to OU, 118 healthy subjects without EAE and 24 MM patients were included to the study.Results: CA125, CA15-3, Folate, Vit B12,ferritin levels of MM patients were higher, fT3 levels of MM were lower.View this table:Table 1. Distribution of sex, age and biochemical findings according to the groupsAUC of the CA125 and CA15-3 in identifying MM were 0.78 and 0.67 in ROC curve respectively.View this table:Table 2. Several cut off values of markers differentiating mesothelioma from benign diseasesOther tumor markers were irrevelant.Conclusion: CA125 and CA15-3 may have role on diagnosis of MM. Ferritin, folate, VitB12 levels were increased in MM patients where as fT3 levels were decreased.