PT  - JOURNAL ARTICLE
AU  - Isa Döngel
AU  - Mehmet Bayram
AU  - Semsettin Sahin
AU  - Ismail Benli
TI  - Investigating of CEA, CA125, CA15-3, CA19-9, fT3, fT4, TSH, vitamin B12, folic acid and ferritin in malignant and benign diseases due to enviromental asbestos exposure
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p1068
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p1068.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p1068.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Aim: To identify several biochemical marker levels in mesothelioma (MM), in subjects with pleural plaques (PP) due to environmental asbestos exposure (EAE) and in healthy subjects with EAE.Method: 277 patients with PP from villages close to ophiolitic units (OU) (serpentin asbest containing), 121 healthy subjects from villages close to OU, 118 healthy subjects without EAE and 24 MM patients were included to the study.Results: CA125, CA15-3, Folate, Vit B12,ferritin levels of MM patients were higher, fT3 levels of MM were lower.View this table:Table 1. Distribution of sex, age and biochemical findings according to the groupsAUC of the CA125 and CA15-3 in identifying MM were 0.78 and 0.67 in ROC curve respectively.View this table:Table 2. Several cut off values of markers differentiating mesothelioma from benign diseasesOther tumor markers were irrevelant.Conclusion: CA125 and CA15-3 may have role on diagnosis of MM. Ferritin, folate, VitB12 levels were increased in MM patients where as fT3 levels were decreased.