TY - JOUR T1 - Impact of drug resistance over sputum conversion in tubercular patients receiving re-treatment regimen JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p2623 AU - Prem Parkash Gupta AU - P.T. Yasir Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p2623.abstract N2 - Background: Previous tubercular treatment is known to be associated with high drug resistance.Objectives: To assess the impact of drug resistance over sputum conversion in tubercular patients receiving supervised re-treatment regimen.Methods: A total of 101 smear positive pulmonary tuberculosis patients [relapse (65), failure (23), and defaulter (13); all with age ≥ 15 years] registered for re-treatment at our Institute were included. Drug susceptibility testing (DST) was done using Lowenstein-Jensen media. All patients were given thrice weekly supervised re-treatment regimen. Sputum microscopy was done in all patients at initiation and also at the end of 1st, 2nd, and 3rd months.Results: 41.50% of patients in relapse group, 85.71% in failure group, and 70% in default group had drug resistance. Sputum conversion during initial three months in relapse group was 29.23%, 60%, 64.61%, respectively; same for failure group was 0%, 0%, 4.36%, respectively; and that for default group was 23%, 38.46%%, 46.15%, respectively. Table-1 shows impact of individual drug resistance on sputum conversion.View this table:Table 1. Sputum conversion across first 3 monthsConclusions: Drug resistance was observed to be the most important determinant for poor sputum conversion across all subcategories in present study. ER -