RT Journal Article
SR Electronic
T1 Evaluating the risk of lower respiratory tract infection (LRTI) hospitalizations due to respiratory distress syndrome (RDS) in late preterm
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1718
VO 38
IS Suppl 55
A1 Katharina Buesch
A1 Hoa Khong
A1 Katherine Gooch
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/1718.abstract
AB Background: Premature birth results in underdeveloped lung function that increases their risk for respiratory infection and morbidity. The prevalence of RDS requiring intervention in premature births is significant, including those considered late preterm. RSV is the most prevalent cause for LRTI hospitalizations in infants. This study sought to determine what the independent risk of RDS diagnosis at birth has on LRTI hospitalisations in late preterm infants during the first year of life.Methods: Late premature infants (33-36 weeks gestational age) hospitalized within the first year of life for a LRTI were extracted from the Medical Claims I3 database (2000-2008). Univariate analyses were conducted to compare the differences between infants with and without an RDS event at birth. A multivariate model was developed to determine the independent association of RDS and LRTI hospitalization. Statistical significance was set at 0.05.Results: 31178 late preterm infants (52% male) were identified during the study timeline. 2297 (7.4%) late preterm infants were hospitalized due to a LRTI; a hyaline membrane disease or RDS diagnosis (ICD-9 code: 769) was observed in 962 late preterms (3%). Multiple logistic regression analysis showed a strong and significant relationship between RDS and LRTI hospitalization (OR 5.2, 95% CI 4.4–6.2).Conclusion: Late preterm infants with RDS event at birth are 5 times more likely to be hospitalized due to LRTI during the first year of life compared to late preterm without RDS event at birth. This risk factor should be considered when evaluating a premature infants risk for respiratory hospitalization.